Genomic & Bioinformatics Analysis Resource (GenBAR)

Genomics & Bioinformatics Analysis Resource (GenBAR)

GenBAR is a Columbia University core facility supported by the Vagelos College of Physicians and Surgeons (VP&S) Office of Research. It is open to all Columbia faculty, research scientists, and students. 

For GenBAR questions, please submit a ticket here.

Bioinformatics Team

The GenBAR Bioinformatics team is responsible for processing Next Generation Sequencing data by using standardized best practices pipelines. All exome and genome samples are processed using a consistent alignment and variant calling pipeline.

Services Provided:

Informatics

  • Whole Genome Data processing
  • Whole Exome Data processing
  • Informatics/IT project support
  • Long-term storage of whole genome sequencing data*
  • Long-term storage of whole exome sequencing data*
  • Short-term storage of whole genome sequencing data*
  • Short-term storage of whole exome sequencing data*
  • Data delivery of Whole Genome sequencing data under a Data Transfer Agreement
  • Data delivery of Whole Exome sequencing data under a Data Transfer Agreement

*Note: fees waived for samples designated as Columbia “control” samples.

 

ATAV (Analysis Tool for Annotated Variants) Database Queries

  • Exome-wide association analysis. Perform case-control association studies of rare coding variants from whole exome or whole genome sequencing data of single nucleotide variants by gene- and region-based collapsing analysis. Includes standard sample quality control checks, genetic ancestry estimation, statistical analysis of rare variant enrichments, and a report summarizing the research findings. Analyses can be performed using standard gene-based collapsing methods or ancestry-clustered testing which can be helpful for mixed ancestry cohorts. Additional charges may be applied for projects that require customized computational methods.
  • Automated diagnostic report of sample sequencing data (raw ATAV output)
  • Data look-up in ATAV

 

If you have any questions, please contact [email protected].

Any questions about setting up iLab, please contact [email protected].