Precision Medicine Conference

When: Thursday, October 10- Friday, October 11th, 2024

Where: Jerome L. Greene Science Center, 3227 Broadway, 9th floor, New York, NY 10027

REGISTER HERE

Please reserve your seat for this exciting two-day conference, Frontiers in Human Genetics. A detailed schedule will be posted closer to the event.

The Symposium will showcase transformative, fundamental research in Human Genetics for a broad audience of biologists and biomedical researchers. To this end, we bring together an interdisciplinary set of speakers (below) to present their work on the causes and consequences of genetic and environmental perturbations of human phenotypes.

Sarah Aitken (Cambridge University)

Nancy Cox (Vanderbilt University)

Michel Georges (Université de Liège)

Anjali Hinch (University of Oxford)

Inigo Martincorena (Sanger Institute)

Gil McVean (University of Oxford/Genomics PLC)

Simon Myers (University of Oxford)

Jennifer Philipps-Cremins (University of Pennsylvania)

Jonathan Pritchard (Stanford University)

Adrianna San Roman (Duke University)

Vijay G. Sankaran (Boston Children/Broad Institute)

Nasa Sinott-Armstrong (University of Washington)

Yun Song (University of California, Berkeley)

Oliver Stegle (European Molecular Biology Laboratories)

Miriam Udler (Mass Gen/Broad Institute)

Precision Medicine Conference: Genome and Chromatin Architecture

Friday, May 19, 2023 | 9:00 AM - 5:00 PM

Roy And Diana Vagelos Education Center, 2nd floor auditorium, 104 Haven Ave., New York, NY 10032

Our topic this year Genome and Chromatin Architecture and Precision Medicine, and our objective is to provide an up-to-date perspective on the relationship between DNA sequence and genome organization in space and time during normal cellular function and in diseased states. We provide examples of the dynamic regulation of genome folding interrogated by state of the art genomic and imaging technologies, and we explore the role of genome polymorphisms in chromatin organization and function. We have been fortunate to assemble and extraordinary group of pioneers in the development and application of technologies that probe and manipulate genome organization, revealing a previously unappreciated role of 3D genome structure dysregulation in human disease. 
 

Schedule: 

9:10am - Marcin Imielinski, MD, PhD, New York University Langone

10:00am - Jane Skok, PhD, New York University

10:50am - Geeta Narlikar, PhD, University of California, San Francisco

11:40am - Bing Ren, PhD, University of California, San Diego

12:30pm - LUNCH (provided in VEC 401)

1:30pm - Stavros Lomvardas, PhD, Columbia University

2:20pm - Jennifer Cremins, PhD, University of Pennsylvania

3:10pm - Anders Sejr Hansen, PhD, Massachusetts Institute of Technology

4:00pm - Alistair Boettiger, PhD, Stanford University

Networking Reception 

GENOMIC INNOVATION AND PRECISION MEDICINE : READING, IMAGING, EDITING AND WRITING THE GENOME

APRIL 5, 2022. 9:00am - 5:00pm

MANHATTANVILLE CAMPUS, THE FORUM AUDITORIUM

EVENT PROGRAM HERE

A key objective of the conference is to provide an up-to-date perspective on the impact of genomic technologies on understanding the functional consequences of disease-associated DNA sequence variation on cellular and organismic function. For example, technologies that simultaneously interrogate RNA transcription, chromatin modification and chromosome structure in individual cells (multi-omics) are making it possible to probe deeply into the functional consequences of DNA sequence variation that associates with disease (at single cell, and single molecule, and atomic resolution). International leaders in the development and application of these technologies will come together to discuss progress and challenges.

Schedule:

8:45am: Registration opens, Atrium at The Forum

9:15am: Jay Shendure, MD, PhD, University of Washington

9:55am: Rahul Satija, PhD, New York Genome Center

10:35am: Joakim Lundeberg, PhD, KTH Royal Institute of Technology

11:15am: Xiaowei Zhuang, PhD, Harvard University

11:55am: Ed Boyden, PhD, Massachusetts Institute of Technology

12:35pm: LUNCH

1:30pm: Feng Zhang, PhD, Massachusetts Institute of Technology

2:10pm: Jef Boeke, PhD, NYU Langone Health

2:50pm: Tuuli Lappalainen, PhD, New York Genome Center

3:30pm: Olga Troyanskaya, PhD, Princeton University; Flatiron Institute

4:10pm: George Church, PhD, Harvard Medical School, Blavatnik Institute

4:50pm: Closing Remarks

5:00pm: Networking reception

Virtual Conference Via Zoom

Event Program

Fifth Annual Columbia Precision Medicine Initiative (CPMI) conference, Advances in Precision Medicine: Genetics of Neurodevelopmental Disease.

The recent past has seen major advances in the understanding of the genetic and genomic architecture of neurodevelopmental disorders. We now have a deeper understanding of how genetic risk for many complex traits including neurodevelopmental disorders is driven by natural selection and distributed across the allelic spectrum.

While reliable results have emerged for conditions ranging from schizophrenia to bipolar disorder to autism, providing important insights into aspects of the neurobiology of these syndromes, a comprehensive understanding of their underlying biology is still out of reach.

In addition to the emerging genetic and molecular advances, there is the increasing realization that neurodevelopmental disorders target specific brain circuits. The interaction between genetic background, brain structure, and brain function is now the scientific background upon which specific neurodevelopmental conditions can be studied and understood.

Please click the links below for the available speakers lecture, or visit our video library here.

Conference Schedule:

Moderated by Thomas Lehner, PhD, MPH

Mark Daly, PhD, Harvard Medical School, University of Helsinki

Elise Robinson, ScD, Harvard T.H. Chan School of Public Health

Matthew State, MD, PhD, University of California, San Francisco

David Goldstein, PhD, Columbia University

Sergiu Pasca, MD, Stanford University

Nenad Sestan, MD, PhD, Yale School of Medicine

Kristen Brennand, PhD, Yale School of Medicine

Huda Zoghbi, MD, Baylor College of Medicine

Columbia Precision Medicine Initiative

Friday, April 24, 2020, 9:50am - 3:15pm

Virtual Conference via Zoom. 

4th Annual Columbia Precision Medicine Initiative (CPMI) conference: Advances in Precision Medicine: Harmonizing Clinical and Genomic Data. 

One of the challenges facing us today is how to leverage the huge amounts of genomic data generated every day through regular patient care? How can this data be integrated into electronic health records in order to generate knowledge in a clinically useful way? 


We learned about the most recent strategies to integrate large amounts of genomic data into electronic health records, to generate clinically-useful knowledge in these presentations. Please find the links to each talk below and also in our video library here.

David Ledbetter, Ph.D., Geisinger

Dan Roden, M.D., Vanderbilt University School of Medicine

Marylyn Ritchie, Ph.D., University of Pennsylvania

Rex L. Chisholm, Ph.D., Northwestern Feinberg School of Medicine

Chunhua Weng, Ph.D., Columbia University

Nancy J. Cox, Ph.D., Director, Vanderbilt University

David Madigan, Ph.D., Columbia University

Nicholas Tatonetti, Ph.D., Columbia University

Full conference program can be found here: https://precisionmedicine.columbia.edu/content/precision-medicine-society-conference-program-april-24-2020

Advances in Precision Medicine: Big Data

Columbia Precision Medicine Initiative 3rd Annual Conference

April 8th, 2019

The Forum, Columbia University, Manhattanville Campus

High-throughput molecular profiling technologies and the increasing availability of clinical data for research and in electronic health records give major opportunities to accelerate precision medicine using a variety of computational methods. We will learn about the latest research in machine learning, genomics, clinical research, electronic health records and data science.

Jeannette Wing, PhD, Columbia University

Ewan Birney, PhD, EMBL-EBI

Big Data in Health and Research, Opportunities, and Challenges

Goncalo Abecasis, PhD, Regeneron

Sequencing and Analysis of 100,000s of Human Genomes

Richard Durbin, PhD, Wellcome Sanger Institute

Rich Bonneau, PhD, New York University

Large-Scale Machine Learning Methods for Predicting Protein Functions from Sequence, Structure and Networks

Ron Shamir, MD, Tel Aviv University

On the Power of Integrated Analysis in Cancer and Precision Medicine

Barbara Engelhardt, PhD, Princeton University

The Importance of Modeling Patient State in Reinforcement Learning for Precision Medicine

George Hripcsak, PhD, Columbia University

Drawing Reproducible Conclusions from Observational Clinical Data

Mihaela van der Schaar, PhD, University of Oxford, UK

Personalized Treatments: Precision Medicine beyond Predictions

Jennifer Listgarten, PhD, University of California, Berkeley

Machine-learning Driven Protein and Molecule Design

Columbia Precision Medicine Initiative Conference - Big Data
Columbia University Big Data Conference

Accomplishing the objectives of CPMI requires advancing basic science, and the application of the resulting knowledge to the identification of genetic causes of human diseases, to the understanding of disease mechanisms, and ultimately to the treatment of a wide range of human diseases—from cancer to neurological diseases. To this end, CPMI is a truly University-wide effort. The bedrock of the initiative is strong basic and translational biomedical science practiced at Columbia University Irving Medical Center, the Zuckerman Institute, and the Morningside campus. Success of the initiative will also require many other academic disciplines at Columbia ranging from humanities, to engineering, to law and business.

With breathtaking advances in DNA sequencing, computer science, and clinical medicine, it is virtually certain that the number of diseases diagnosed and treated on the basis of genome sequence information will increase dramatically during the next decade. In addition, as we learn more about the relationship between genetic mutations, human biology, and disease, the genome sequence will play a central role in the practice of medicine. I believe that Columbia University, as a great liberal arts and scientific institution, is ideally positioned to bring the full force of an extraordinarily diverse and talented faculty to bear on the advancement of precision medicine.

Columbia University is a world leader in medicine, science, and technology, from fundamental discoveries to the clinic. The Columbia Precision Medicine Initiative (CPMI) utilizes the vast intellectual resources of Columbia faculty to drive this revolution in health care.

Advances in Precision Medicine: Cancer Genomics was held on Monday April 9th, 2018, on the Columbia University Medical Campus. We hosted 10 top international speakers, together bringing a broad focus spanning from research insights to clinical applications of cancer genomics.

Arul M. Chinnaiyan, University of Michigan

Luis Diaz, Memorial Sloan Kettering Cancer Center

Arnold Levine, Institute for Advanced Studies

William C. Hahn, Broad Institute; Dana-Farber Cancer Institute

Serena Nik-Zainal, University of Cambridge

Raul Rabadan, Columbia University

Nitzan Rosenfeld, University of Cambridge

Charles Sawyers, Memorial Sloan Kettering Cancer Center

David Tuveson, Cold Spring Harbor Laboratory

Catherine Wu, Broad Institute; Dana-Farber Cancer Institute

CPMI 2nd Annual Conference
CPMI 2nd Annual Conference
CPMI 2nd Annual Conference
CPMI 2nd Annual Conference

At the Inaugural Columbia Precision Medicine Initiative (CPMI) conference: Advances in Precision Medicine: Genetics, we heard about cutting-edge genetics research from international leaders in the field whose research advances the basic science of genetics and impacts the application of genetics to the understanding and treatment of human genetic disease. 

Accomplishing the objectives of CPMI requires advancing basic science, and the application of the resulting knowledge to the identification of genetic causes of human diseases, the understanding of disease mechanisms, and ultimately to the treatment of a wide range of human diseases ranging from cancer to neurological diseases. To this end, CPMI is a truly University-wide effort. The bedrock of the initiative is strong basic and translational biomedical science practiced in the Medical School, the new Zuckerman Mind Brain and Behavior Institute, and the Morningside campus. Success of the Initiative will also require many other academic disciplines at Columbia ranging from humanities, to engineering, to law and business.

With breathtaking advances in DNA sequencing, computer science, and clinical medicine, it is virtually certain that the number of diseases diagnosed and treated on the basis of genome sequence information will increase dramatically during the next decade. In addition, as we learn more about the relationship between genetic mutations, human biology, and disease, the genome sequence will play a central role in the practice of medicine. I believe the technology is here and essential groundwork has been established. Columbia University is ideally positioned to bring the full force of an extraordinarily diverse and talented faculty to bear on the advancement of precision medicine. 

John Hardy, PhD: Personalized Medicine for the Major Neurodegenerative Diseases: Genetic Predictions & Mechanistic Insights 

Jonathan Pritchard, PhD: The Genetic Architecture of Complex Traits: From Polygenic to Omnigenic

David Goldstein, PhD: Precision Neurology 2017

CPMI Conference 2017
CPMI Conference 2017
CPMI Conference 2017