Mouse Genome Editing Awards
Past Awardees
The Initiative supports awards for mouse genome editing with the objective of funding the generation of mouse models of human disease.
Mouse models of Stargardt disease for hypomorphs and modifiers
Rando Allikmets, PhD and Takayuki Nagasaki, PhD; Department of Opthalmology
Two different neurological diseases are caused by different mutations in the Pumilio1 gene
Vincenzo Genarrino, PhD; Department of Genetics & Development, Pediatrics and Neurology
Generation of mouse models of schizophrenia risk mutations in the SETD1A gene
Joseph Gogos, MD, PhD; Professor of Physiology and Cellular Biophysics, Neuroscience and Psychiatry (in the Mortimer B. Zuckerman Mind Brain Behavior Institute)
Murine models of FHOD3 mutations causing hypertropic and dilated cardiomyopathy
John P. Morrow, MD; Department of Medicine; Gregg G. Gundersen, PhD; Howard J. Worman, MD; Pathology and Cell Biology
Mouse model to establish the role of ARNT2 in the weight regulation pathway
Vidhu Thaker, MD; Department of Pediatrics
Precision SNP therapeutic Editing for Autosomal Dominant Retinitis Pigmentosa
Stephen Tsang, MD, PhD; Department of Ophthalmology
The supplemental funding for mouse models is made possible by the generous gift of Roy and Diana Vagelos, to the CPMI, and it is intended to support ground-breaking research in the field of precision medicine.
G protein signaling in a new neurodevelopmental disorder: A molecular and neuronal investigation of GNB1 Encephalopathy
David Goldstein, Professor, Director, Institute for Genomic Medicine
DDX10as a Precision Medicine target for the Acute Respiratory Distress Syndrome (ARDS)
Jahar Bhattacharya, MD, DPhil, Professor of Medicine Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine
Novel mouse models of human cardiomyopathy and skeletal myopathy based on a human FLNCc.7416_7418delGAA mutation”
Wendy K. Chung, MD, PhD, Kennedy Professor of Pediatrics; Carrie Welch, PhD, Assistant Professor of Medical Sciences
The role of the RNA binding protein Pumilio1 in two different neurological diseases
Vincenzo A. Gennarino, Ph.D., Genetics & Development, Pediatrics and Neurology
Awards funds to subsidize the creation of mouse models of human disease, using molecular tool, CRISPR/Cas9. Review process is complete and four proposals have been selected for funding.
Modeling HCN1 gene variants associated with human early infantile epileptic encephalopathy (EIEE) in mice
Jonathan Barasch, Professor of Medicine and Pathology and Cell Biology
A humanized mouse model to study the immunopathology of vitiligo.
Remi Creusot, PhD, Assistant Professor in the Department of Medicine and principal investigator at the Columbia Center for Translational Immunology and the Naomi Berrie Diabetes Center
Molecular Genetics of FTO.
Rudolph Leibel, Christopher J. Murphy Memorial Professor of Diabetes Research and Professor of Pediatrics and Medicine; Co-Director, Naomi Berrie Diabetes Center
Precision SNP Editing for Autosomal Dominant Retinitis
Stephen Tsang, MD, PhD, Associate Professor, Edward S. Harkness Eye Institute
Awards funds to subsidize the creation of mouse models of human disease, using molecular tool, CRISPR/Cas9. Review process is complete and five proposals have been selected for funding.
Modeling HCN1 gene variants associated with human early infantile epileptic encephalopathy (EIEE) in mice
Steven A. Siegelbaum, Professor and Chair, Department of Neuroscience
The role of Wdfy3 in CNS development and disease.
Ai amamoto, Ph.D., Department of Neurology
The Parkinson's disease associated GBA variant, E326K, as a therapeutic target
Lorraine N. Clark, Ph.D., Associate Professor and Assistant Medical Director, PCB, LPGM and Taub Institute for research on Alzheimer's disease and the aging brain
Mouse models of intellectual disability with novel lissencephaly associated with CRADD mutations
Carol M. Troy, MD, PhD, Professor of Pathology & Cell Biology
De novo truncating mutations in TRIM8 define a novel syndrome characterized by childhood epilepsy, focal segmental glomerulosclerosis (FSGS), and vesicoureteral reflux (VUR).
Simone Sanna-Cherchi, Florence Irving Assistant Professor of Medicine Paul Marks Scholar, Division of Nephrology - Columbia University College of Physicians and Surgeons