Join us in celebrating Tom Maniatis’ 80th Birthday. Tom and his students and post-doctoral trainees pioneered the development of genomic technology, and its application to the study of the molecular mechanisms of gene regulation. Their cloning of the human β-globin gene cluster in 1978 provided the means of isolating genes and identifying mutations that result in defects in transcription and RNA splicing associated with β-thalassemia, and to advances in the understanding of the mechanisms of transcription and RNA splicing. Their studies of the human β-interferon gene led to the discovery of multi-protein enhancer complexes (enhanceosomes) that regulate gene expression, and the role of the ubiquitin proteosome pathway in the activation of innate immunity. This, in turn, led to important insights into the mechanisms by which autophagy and neuroinflammation accelerate disease progression in ALS. Most recently, the lab has focused on the complex genomic organization and expression of the protocadherin gene cluster, which has led to insights into mechanisms by which complex “barcodes” are generated on the surface of all neurons, and how clustered protocadherins function in neural circuit assembly. Former members of the Maniatis lab will present their recent work.
Schedule of speakers:
9:00 - 9:05a Welcome Remarks
9:05 – 9:15am Richard Axel
RNA
9:15 - 9:35a Anne Ephrussi, EMBL
9:35 - 9:55a Kristen Lynch, UPenn
9:55 - 10:15a Brent Gravely, University of Connecticut
Coffee Break 10:15 - 10:45
Disease
10:45 - 11:05a Valeria Gerbino, Milan
11:05 - 11:35a Richard Treisman, Crick Institute
11:35 - 11:55a Mary Lynn Hedley, Broad Institute
11:55a - 12:15p Ted Abel, University of Iowa
Lunch Break 12:15 – 1:00p
1:00 – 1:10p Roy Vagelos
Immunity
1:10 - 1:30p James Chen, UT Southwestern
1:30 - 1:50p Ben tenOever, NYU Langone Health
1:50 - 2:10p Olie Rando, UMass
2:10 - 2:30p Kevin Monahan, Rutgers University
Coffee Break 2:30 - 2:50p
Genomics
2:50 - 3:20p Argiris Efstratiadis, Academy of Athens
3:20 - 3:40p Rick Myers, HudsonAlpha
3:40 - 4:00p Bosiljka Tasic, Allen Institute
4:00 - 4:20p Daniele Canzio, UCSF
4:20 - 4:40p Silas Maniatis, NYGC
Concluding Remarks: Charles Zuker and final word by Tom Maniatis
5:00pm: Networking reception in Atrium at The Forum