Genetic Influences on Human Hematopoiesis
ABSTRACT
In this presentation, I will discuss work from our laboratory exploring how naturally occurring genetic variation in humans can alter the process of blood and immune cell production, or hematopoiesis, in health and disease. I will illustrate how integrating human genetic studies with diverse functional methods offers profound mechanistic insights, enhancing our understanding of hematopoiesis. Additionally, I will discuss recent work exploring how variable expressivity can arise in blood disorders at both a genetic and mechanistic level.
