How Our Genomic Landscape Is Reshaped in the Making of Eggs and Sperm
ABSTRACT
The DNA sequence in each egg and sperm is unique, a mosaic created by the shuffling of chromosomes by the process of recombination. At a cellular scale, recombination is essential for producing healthy eggs and sperm. At the scale of populations, recombination generates genetic diversity that underpins the evolution of species. In this talk, I will show how our understanding of the biological mechanisms underlying recombination has been powered by combining human genetic data and genomic experiments from these opposing scales.
